Lack of association between genetic polymorphisms within KCNQ1 locus and type 2 diabetes in Tunisian Arabs
作者: Amira TurkiNabil MtiraouiAmna S. Al-BusaidiMoncef KhirallahTouhami MahjoubWassim Y. Almawi
作者单位: 1Research Unit of Biology and Genetics of Cancer and Haematological and Autoimmune Diseases, Faculty of Pharmacy of Monastir, University of Monastir, Monastir, Tunisia
2Higher Institute of Biotechnology of Monastir, University of Monastir, Tunisia
3Department of Medical Biochemistry, College of Medicine & Medical Sciences, Arabian Gulf University, Manama, Bahrain
4Department of Ophtalmology, CHU Fattouma Bourguiba, Monastir, Tunisia
刊名: Diabetes Research and Clinical Practice, 2012, Vol.98 (3), pp.452-458
来源数据库: Elsevier Journal
DOI: 10.1016/j.diabres.2012.10.006
关键词: AlleleHaplotypeKCNQ1TunisiaType 2 diabetes
原始语种摘要: Abstract(#br)Aims(#br)Polymorphisms of KCNQ1 were previously associated with type 2 diabetes (T2DM) in select Caucasian and non-Caucasian populations. We investigated the association of rs231361, rs231359, rs151290, rs2237892, rs2283228, rs2237895, and rs2237896 KCNQ1 polymorphisms with T2DM in Tunisian Arabs.(#br)Subjects and methods(#br)Subjects comprised 900 T2DM patients and 600 normoglycemic controls. KCNQ1 genotyping was done by allelic discrimination (real-time PCR) and PCR-RFLP methods; the contribution of KCNQ1 polymorphisms to T2DM were analyzed by Haploview and regression analysis.(#br)Results(#br)Minor allele frequency (MAF) of the 7 tested KCNQ1 variants was comparable between T2DM cases and controls. Mild association of rs2237892 genotypes with T2DM was seen ( P ...
全文获取路径: Elsevier  (合作)
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影响因子:2.741 (2012)

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关键词翻译
关键词翻译
  • association 联合
  • genetic 遗传的
  • locus 轨迹
  • diabetes 糖尿病
  • within 在以内
  • contained 容纳的
  • remaining 剩余
  • tested 已试验的
  • normoglycemic 血糖量正常的
  • haplotype 单倍体型