Protective role of benzoselenophene derivatives of resveratrol on the induced oxidative stress in intestinal myofibroblasts and osteocytes
作者: Vladana DomazetovicFilippo FontaniDamiano TaniniVeronica D'EsopoCaterina ViglianisiGemma MarcucciLucia PanzellaAlessandra NapolitanoMaria Luisa BrandiAntonella CapperucciStefano MenichettiMaria Teresa VincenziniTeresa Iantomasi
作者单位: 1Department of Biomedical, Experimental and Clinical Sciences “Mario Serio”, University of Florence, Viale Morgagni 50, I-50134 Florence, Italy
2Department of Chemistry “Ugo Schiff”, University of Florence, Via della Lastruccia3-13, I-50019 Sesto Fiorentino, Italy
3Department of Surgery and Translational Medicine, Bone Metabolic Diseases Unit, University of Florence, Viale Pieraccini 6, I-50139 Florence, Italy
4Department of Chemical Sciences, University of Naples “Federico II”, Via Cintia 4, I-80126 Naples, Italy
刊名: Chemico-Biological Interactions, 2017, Vol.275 , pp.13-21
来源数据库: Elsevier Journal
DOI: 10.1016/j.cbi.2017.07.015
关键词: ResveratrolBenzoselenophene derivativesAntioxidantsMyofibroblastsOsteocytes
原始语种摘要: Abstract(#br)Resveratrol (RE), a polyphenolic compound present in some food and plants, is characterized by anti-inflammatory and antioxidant properties. However, it is quickly metabolized with consequent loss of its efficacy. In this study, the antioxidant effect of 2-phenyl-benzoselenophene derivatives (VD0, VD1 and VD2) was detected in intestinal myofibroblast and osteocyte cell lines in which the oxidative stress was induced by GSH depletion or starvation, respectively. In fact, the oxidative stress is involved in pathogenesis of inflammatory bowel diseases (IBD) and in increased osteoclastogenesis in osteoporosis. Our results show that these derivatives have major antioxidant power in reducing and/or restoring radical oxygen species to control values than RE itself in both cell...
全文获取路径: Elsevier  (合作)
影响因子:2.967 (2012)

  • resveratrol 白藜芦醇
  • oxidative 氧化的
  • intestinal 肠的
  • induced 感应的
  • stress 应力
  • derivatives 派生物