Enhanced intracellular uptake and stability of umbelliferone in compound mixtures from Angelica gigas in vitro
作者: Yoon Young KangJun Yeong KimJihyeon SongHyejung Mok
作者单位: 1Department of Bioscience and Biotechnology, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea
刊名: Journal of Pharmacological Sciences, 2019, Vol.140 (1), pp.8-13
来源数据库: Elsevier Journal
DOI: 10.1016/j.jphs.2019.02.010
关键词: UmbelliferoneCompound mixtureAngelica gigasSynergistic biological effect
原始语种摘要: Abstract(#br)Understanding how natural compounds work together for disease treatments can improve their clinical efficacy and therapeutic effects. To elucidate the mechanisms of synergistic biological effects in natural compound mixtures, umbelliferone (UMB, 7-hydroxycoumarin), derived from Angelica (A.) gigas , was selected as active compound with fluorescent characteristic to examine bioactivities in vitro in the presence of other compounds from Angelica gigas . Antioxidant effects of UMB in biochemical assays and cellular reactive oxygen species (ROS) levels in RAW264.7 cells were not significantly improved by addition of other compounds. However, intracellular uptake, inhibition of the efflux pump P-glycoprotein (P-gp), and physiological stability of UMB were greatly enhanced by the...
全文获取路径: Elsevier  (合作)
影响因子:2.15 (2012)

  • umbelliferone 散形酮
  • Angelica 当归
  • compound 复合物
  • intracellular 胞内的
  • mixtures 混合料
  • uptake 上风口
  • vitro 体外
  • stability 稳定性