Size-related cytotoxicological aspects of polyvinylpyrrolidone-capped platinum nanoparticles
作者: Hana BuchtelovaSimona DostalovaPetr MichalekSona KrizkovaVladislav StrmiskaPavel KopelDavid HynekLukas RichteraAndrea RidoskovaPavlina AdamJindrich KynickyMartin BrtnickyZbynek HegerVojtech Adam
作者单位: 1Department of Chemistry and Biochemistry, Mendel University in Brno, Zemedelska 1, CZ-613 00 Brno, Czech Republic
2Central European Institute of Technology, Brno University of Technology, Purkynova 123, CZ-612 00 Brno, Czech Republic
3Department of Geology and Pedology, Mendel University in Brno, Zemedelska 1, CZ-613 00 Brno, Czech Republic
刊名: Food and Chemical Toxicology, 2017, Vol.105 , pp.337-346
来源数据库: Elsevier Journal
DOI: 10.1016/j.fct.2017.04.043
关键词: Comet assayCytotoxicityHaemocompatibilityNanomedicineReactive oxygen species
英文摘要: Abstract(#br)The nanotechnological concept is based on size-dependent properties of particles in the 1–100 nm range. Nevertheless, the connection between their size and effect is still not clear. Thus, we focused on reductive colloidal synthesis, characterization and biological testing of Pt nanoparticles (PtNPs) capped with biocompatible polymer polyvinylpyrrolidone (PVP). Synthesized PtNPs were of 3 different primary sizes (approx. ∼10; ∼14 and > 20 nm) and demonstrated exceptional haemocompatibility. In vitro treatment of three different types of malignant cells (prostate – LNCaP, breast – MDA-MB-231 and neuroblastoma – GI-ME-N) revealed that even marginal differences in PtNPs diameter resulted in changes in their cytotoxicity. The highest cytotoxicity was observed using the smallest...
全文获取路径: Elsevier  (合作)
影响因子:3.01 (2012)

  • capped 去蒂
  • platinum 
  • related 有关的