Dendrobine-type alkaloids and bibenzyl derivatives from Dendrobium findlayanum
作者: Gui-Yuan LiuLu TanLei ChengLi-Sheng DingYan ZhouYun DengYu-Qi HeDa-Le GuoShi-Ji Xiao
作者单位: 1School of Pharmacy, Zunyi Medical University, Zunyi 563006, China
2School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China
3Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi 563006, China
4Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China
刊名: Fitoterapia, 2020, Vol.142
来源数据库: Elsevier Journal
DOI: 10.1016/j.fitote.2020.104497
关键词: OrchidaceaeDendrobium findlayanumAlkaloidBibenzylCytotoxicityGastrointestinal motility
原始语种摘要: Abstract(#br)Five previously undescribed compounds, including two dendrobine-type alkaloids ( 1 and 2 ), three bibenzyl derivatives ( 3 – 5 ), along with six known compounds were isolated from orchids Dendrobium findlayanum . The structures and absolute configurations of the undescribed compounds were elucidated on the basis of HR-ESIMS, NMR spectroscopy, optical rotation value, as well as electronic circular dichroism (ECD) calculations. The cytotoxic effects of the isolated compounds on three human tumour cell lines (A172, SHSY5Y, and Hela) were evaluated by the MTT assay. Compound 6 showed excellent inhibitory activities against three human tumour cell lines with IC 50 ranging from 1.65 μM to 3.77 μM. All these compounds were assessed for their activity of promoting the...
全文获取路径: Elsevier  (合作)
影响因子:2.231 (2012)

  • bibenzyl 联苄
  • alkaloids 生物碱类
  • derivatives 派生物
  • motility 游动性