Human Endogenous Retroviruses in Neurological Diseases
作者: Patrick KüryAvindra NathAlain CréangeAntonina DoleiPatrice MarcheJulian GoldGavin GiovannoniHans-Peter HartungHervé Perron
作者单位: 1Department of Neurology, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany
2Section of infections of the Nervous System, National Institute of Neurological Diseases and Stroke (NINDS), National Institutes of Health (NIH), Bethesda, MD, USA
3Service de Neurologie, Groupe Hospitalier Henri Mondor, Assistance Publique Hopitaux de Paris (APHP), Université Paris Est, Créteil, France
4Department of Virology, University of Sassari, Sassari, Italy
5Institute for Advanced Biosciences (IAB), University of Grenoble-Alpes, La Tronche, France
6Institut National de la Santé et de la Recherche Médicale (INSERM) Unité 1209, La Tronche, France
7Centre for Neuroscience and Trauma, Blizard Institute, Queen Mary University, London, UK
8The Albion Centre, Prince of Wales Hospital, Sydney, Australia
9Geneuro, Plan les Ouates, Geneva, Switzerland
10University of Lyon, Lyon, France
刊名: Trends in Molecular Medicine, 2018, Vol.24 (4), pp.379-394
来源数据库: Elsevier Journal
DOI: 10.1016/j.molmed.2018.02.007
原始语种摘要: The causes of multiple sclerosis and amyotrophic lateral sclerosis have long remained elusive. A new category of pathogenic components, normally dormant within human genomes, has been identified: human endogenous retroviruses (HERVs). These represent ∼8% of the human genome, and environmental factors have reproducibly been shown to trigger their expression. The resulting production of envelope (Env) proteins from HERV-W and HERV-K appears to engage pathophysiological pathways leading to the pathognomonic features of MS and ALS, respectively. Pathogenic HERV elements may thus provide a missing link in understanding these complex diseases. Moreover, their neutralization may represent a promising strategy to establish novel and more powerful therapeutic approaches.
全文获取路径: Elsevier  (合作)
影响因子:9.571 (2012)

  • powerful 强大的
  • represent 代表
  • expression 表示
  • pathognomonic 特殊的
  • sclerosis 硬化
  • understanding 理解
  • neutralization 中和
  • novel 长篇小说
  • endogenous 内成的
  • engage 从事