Sensing arterial CO 2 levels: a role for medullary P2X receptors
作者: K.M SpyerT Thomas
作者单位: 1Royal Free and University College Medical School, University College London, Rowland Hill Street, London NW3 2PF, UK
刊名: Journal of the Autonomic Nervous System, 2000, Vol.81 (1), pp.228-235
来源数据库: Elsevier Journal
DOI: 10.1016/S0165-1838(00)00118-1
关键词: CO 2Ventrolateral medullaPurinoreceptorsRespirationhomeospasis
原始语种摘要: Abstract(#br)ATP has been shown to act as an excitatory neurotransmitter in the central nervous system. In this review, evidence is presented to indicate that when ATP is micro-injected into the ventrolateral medulla (VLM) of the rat, changes in respiratory activity are elicited. These effects, and accompanying changes in heart rate and blood pressure are mediated by P2X purinoreceptors. Immunocytochemistry indicates a prevalence of P2X 2 and P2X 6 purinoreceptors in this region of the medulla. The P2 purinoceptor antagonists, suramin and PPADS blunt the respiratory responses to changes in arterial CO 2 levels when micro-injected into the VLM. This effect is shown electrophysiologically to be mediated by purinoreceptors located primarily on respiratory neurones of the VLM including the...
全文获取路径: Elsevier  (合作)
影响因子:1.846 (2012)

  • arterial 动脉的
  • medullary 脊髓的
  • respiratory 呼吸过程
  • suramin 苏拉明
  • central 中心的
  • inspiratory 吸气的
  • micro 
  • activation 活化
  • lowering 降低
  • ventrolateral 腹侧的