Alleviative effect of fucoxanthin-containing extract from brown seaweed Laminaria japonica on renal tubular cell apoptosis through upregulating Na + /H + exchanger NHE1 in chronic kidney disease mice
作者: Yen-Cheng ChenChung-Yi ChengChung-Te LiuYuh-Mou SueTso-Hsiao ChenYung-Ho HsuPai-An HwangCheng-Hsien Chen
作者单位: 1Division of Nephrology, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan
2Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
3Division of Nephrology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan
4Department of Bioscience and Biotechnology, National Taiwan Ocean University, Taiwan
刊名: Journal of Ethnopharmacology, 2018, Vol.224 , pp.391-399
来源数据库: Elsevier Journal
DOI: 10.1016/j.jep.2018.06.023
关键词: Doxorubicin (Pubchem CID: 443939)Fucoxanthin (Pubchem CID: 5281239)ApoptosisChronic kidney diseaseFucoxanthinNa + /H + exchanger isoform 1Peroxisome proliferator-activated receptor alpha
原始语种摘要: Abstract(#br)Ethnopharmacological relevance(#br)Brown seaweed is a common food for Asians, and the bioactive ingredient fucoxanthin exerts anti-apoptotic activities in several cell types. Renal tubular cell apoptosis is one of the common cellular events leading to renal fibrosis and chronic kidney disease (CKD). However, the influence of fucoxanthin-containing brown seaweed extract on CKD is still unknown. We intended to evaluate the inhibitory effect of fucoxanthin-containing extract from brown seaweed on renal apoptosis under CKD condition and its molecular mechanism.(#br)Materials and methods(#br)The fucoxanthin-containing brown seaweed extract (LJE) was prepared from Laminaria japonica . We investigated how LJE influences on both doxorubicin-treated rat renal tubular cells (NRK-52E)...
全文获取路径: Elsevier  (合作)
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影响因子:2.755 (2012)

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关键词翻译
关键词翻译
  • fucoxanthin 岩藻黄素
  • renal 肾的
  • seaweed 海藻
  • tubular 管状的
  • effect 效应
  • exchanger 交换器
  • brown 褐色
  • extract 提取
  • CKD ChecKing Operator
  • apoptosis 细胞死