Understanding why REDUCE-IT was positive – Mechanistic overview of eicosapentaenoic acid
作者: William S. Harris
作者单位: 1Department of Internal Medicine, Sanford School of Medicine, University of South Dakota, and OmegaQuant Analytics, LLC, Sioux Falls, SD, United States of America
刊名: Progress in Cardiovascular Diseases, 2019, Vol.62 (5), pp.401-405
来源数据库: Elsevier Journal
DOI: 10.1016/j.pcad.2019.10.008
关键词: Eicosapentaenoic acidOmega-3 fatty acidsCardiovascular diseaseInflammationHyperlipidemia
英文摘要: Abstract(#br)The REDUCE-IT study found that patients at elevated risk for cardiovascular disease (CVD) who were already taking statins obtained a marked benefit by taking 4 g/d of eicosapentaenoic acid ethyl esters (icosapent ethyl, IPE; Vascepa) over about 5 years. Although approved for triglyceride (TG) lowering, IPE had only a modest TG-lowering effect in REDUCE-IT, largely because median TG levels were relatively low already. Hence the question of what mechanisms IPE might be working through is of great interest. At present, it appears that the best mechanistic candidates would be anti-platelet effects and/or anti-inflammatory effects. Whatever the cause, the powerful effects of IPE on CVD risk have renewed interest in the clinical utility of omega-3 fatty acids.
全文获取路径: Elsevier  (合作)
影响因子:4 (2012)

  • Omega 希腊字母的最后一字(Ω,ω)奥米伽(导航系统)希腊字母的末一字
  • fatty 脂肪的
  • overview 概观
  • positive 阳片
  • disease