Safety and tolerability of adjunctive brivaracetam in epilepsy: In-depth pooled analysis
作者: Christian BrandtPavel KleinVincent BadalamentiTeresa GasallaJohn Whitesides
作者单位: 1Bethel Epilepsy Centre, Mara Hospital, Maraweg 21, 33617 Bielefeld, Germany
2Mid-Atlantic Epilepsy and Sleep Center, Champlain Building, 6410 Rockledge Drive #610, Bethesda, MD 20817, USA
3UCB Pharma, 8010 Arco Corporate Drive, Raleigh, NC 27617, USA
刊名: Epilepsy & Behavior, 2020, Vol.103 (Pt A)
来源数据库: Elsevier Journal
DOI: 10.1016/j.yebeh.2019.106864
关键词: Antiepileptic drugEpilepsyBrivaracetamAdjunctiveSafetyTolerability
英文摘要: Abstract(#br)Objective(#br)The objective of this analysis was to provide a comprehensive analysis of safety data for adjunctive brivaracetam (BRV), an antiepileptic drug (AED) of the racetam class, for treatment of focal seizures in patients with epilepsy.(#br)Methods(#br)Data were pooled from two phase II, placebo-controlled, double-blind, dose-ranging trials (N01114 [ ClinicalTrials.gov : NCT00175929 ], N01193 [ NCT00175825 ]) and three phase III, placebo-controlled, double-blind, 12-week trials (N01252 [ NCT00490035 ], N01253 [ NCT00464269 ], and N01358 [ NCT01261325 ]) in patients aged ≥16 years with focal seizures, as well as a phase III, placebo-controlled, double-blind, 16-week trial in patients aged ≥16 years with focal or generalized epilepsy...
全文获取路径: Elsevier  (合作)
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影响因子:1.844 (2012)

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关键词翻译
关键词翻译
  • epilepsy 癫痫
  • tolerability 可容许性
  • adjunctive 附属
  • analysis 分析
  • depth