Gingival overgrowth in cyclosporine, tacrolimus, or sirolimus-based immunosuppressive regimens and the single nucleotide IL-6 (−174 G/C) gene polymorphism
作者: Luís Otávio Miranda CotaMichelle Beatriz VianaPaula Rocha MoreiraRicardo Santiago GomezJosé Roberto CortelliSheila Cavalca CortelliFernando Oliveira Costa
作者单位: 1Department of Dental Clinics, Oral Pathology and Oral Surgery, School of Dentistry, Federal University of Minas Gerais, Belo Horizonte, Brazil
2Avenida Antonio Carlos, 6627 Pampulha, PO Box 359, Zip Code 31270-901, Belo Horizonte, MG, Brazil
3Department of Dentistry, Periodontics Research Division, University of Taubaté, Taubaté, São Paulo, Brazil
4Avenida Nove de Julho, 245 Centro, Zip Code 12020-200, Taubaté, SP, Brazil
刊名: Archives of Oral Biology, 2010, Vol.55 (7), pp.494-501
来源数据库: Elsevier Journal
DOI: 10.1016/j.archoralbio.2010.04.001
关键词: ImmunosuppressantsGingival overgrowthInterleukin-6PolymorphismRenal transplantation
原始语种摘要: Abstract(#br)Objective(#br)Interleukin-6 (IL-6) may be involved in drug-induced gingival overgrowth (GO). The present study was conducted to assess the association between IL-6 (−174 G/C) gene polymorphism and GO in renal transplant recipients under cyclosporine (CsA), tacrolimus (Tcr), or sirolimus (Sir)-based regimens.(#br)Methods(#br)Within an eligible population, 45 unrelated subjects were selected for each CsA, Tcr, and Sir group, totaling a sample of 135 subjects. GO was visually assessed and subjects were assigned as controls (non-responders) or cases (responders) in a post hoc definition. IL-6 gene polymorphism was assessed using the polymerase chain reaction amplification and digestion. The distribution of genotypes and allele frequencies in responders and non-responders were...
全文获取路径: Elsevier  (合作)
影响因子:1.549 (2012)

  • nucleotide 核苷酸
  • tacrolimus 血流谱
  • polymorphism 多晶形
  • overgrowth 生长过度
  • observed 观察到的
  • gingival 齿龈的
  • association 联合
  • eligible 符合被推选条件
  • involved 涉及
  • allele 等位基因