Postprandial VLDL-TG metabolism in type 2 diabetes
作者: Esben SøndergaardRakel Fuglsang JohansenMichael D. JensenSøren Nielsen
作者单位: 1Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Nørrebrogade 44, 8000 Aarhus C, Denmark
2Danish Diabetes Academy, Odense University Hospital, Kløvervænget 10, Entrance 112, 3rd floor, 5000 Odense C, Denmark
3Endocrine Research Unit, Mayo Clinic, 1216 2nd St SW, Rochester, MN 55902, USA
刊名: Metabolism, 2017, Vol.75 , pp.25-35
来源数据库: Elsevier Journal
DOI: 10.1016/j.metabol.2017.07.002
关键词: VLDLTriglyceridePostprandial periodLipid metabolismType 2 diabetes
英文摘要: Abstract(#br)Background(#br)Type 2 diabetes is associated with excess postprandial lipemia due to accumulation of chylomicrons and VLDL particles. This is a risk factor for development of cardiovascular disease. However, whether the excess lipemia is associated with an impaired suppression of VLDL-TG secretion and/or reduced clearance into adipose tissue is unknown.(#br)Objective(#br)We measured the postprandial VLDL-TG secretion, clearance and adipose tissue storage to test the hypothesis that impaired postprandial suppression of VLDL-TG secretion, combined with impaired VLDL-TG storage in adipose tissue, is associated with excess postprandial lipemia.(#br)Design(#br)We studied 11 men with type 2 diabetes and 10 weight-matched non-diabetic men using ex-vivo labeled VLDL-TG tracers during...
全文获取路径: Elsevier  (合作)
影响因子:3.096 (2012)

  • diabetes 糖尿病
  • metabolism 代谢
  • VLDL 极低密度脂蛋白
  • period