Early morphological changes in cardiac mitochondria after subcutaneous administration of trastuzumab in rabbits: possible prevention with oral selenium supplementation
作者: Heather S. Laird-FickHemasri TokalaSamanjit KandolaMichael KehdiAugusta PelosiLing WangBrian Grondahl
作者单位: 1Michigan State University College of Human Medicine, East Lansing, MI, USA
2Michigan State University College of Veterinary Medicine, East Lansing, MI, USA
3Western Michigan University, Kalamazoo, MI, USA
4Veterinary Heart Center, Juno, Florida, USA
5EW Sparrow Hospital, Lansing, MI, USA
刊名: Cardiovascular Pathology, 2020, Vol.44
来源数据库: Elsevier Journal
DOI: 10.1016/j.carpath.2019.107159
关键词: TrastuzumabCardiotoxicityHER2ChemopreventionSeleniumElectron microscopy
英文摘要: Abstract(#br)Trastuzumab-mediated cardiotoxicity poses a significant challenge in the treatment of human epidermal growth factor receptor 2-positive breast cancer. To understand the underlying mechanisms, we conducted experiments to determine ultrastructural changes of rabbit cardiac tissue under different experimental conditions, including differing doses of trastuzumab and supplementation with oral sodium selenite, an antioxidant. Histopathology revealed lymphocyte and macrophage infiltration in myocardium of rabbits receiving four doses of trastuzumab. Transmission electron microscopy showed substantial changes with trastuzumab, including edema with separation of myofibril bundles and rupture of sarcomeres. Within mitochondria, edema resulted in disorganization of the cristae. Some...
全文获取路径: Elsevier  (合作)
影响因子:2.352 (2012)

  • mitochondria 线粒体
  • subcutaneous 皮下的
  • selenium 
  • prevention 妨碍
  • possible 可能的
  • administration 管理
  • morphological 形态学的
  • cardiac 贲门
  • after 在之后