Childhood trauma as a risk factor for the onset of subclinical psychotic experiences: Exploring the mediating effect of stress sensitivity in a cross-sectional epidemiological community study
作者: Wulf RösslerVladeta Ajdacic-GrossStephanie RodgersHelene HakerMario Müller
作者单位: 1Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, Switzerland
2Institute of Psychiatry, Laboratory of Neuroscience (LIM 27), University of Sao Paulo, Brazil
3Zurich Programme for Sustainable Development of Mental Health Services, Zurich, Switzerland
4Translational Neuromodeling Unit, Institute for Biomedical Engineering, University of Zurich & ETH Zurich, Switzerland
刊名: Schizophrenia Research, 2016, Vol.172 (1-3), pp.46-53
来源数据库: Elsevier Journal
DOI: 10.1016/j.schres.2016.02.006
关键词: Childhood traumaStress sensitivitySubclinical psychotic experiencesExtended psychosis phenotypePath modeling
英文摘要: Abstract(#br)Childhood trauma is a risk factor for the onset of schizophrenic psychosis. Because the psychosis phenotype can be described as a continuum with varying levels of severity and persistence, childhood trauma might likewise increase the risk for psychotic experiences below the diagnostic threshold. But the impact of stressful experiences depends upon its subjective appraisal. Therefore, varying degrees of stress sensitivity possibly mediate how childhood trauma impacts in the end upon the occurrence of subclinical psychotic experiences.(#br)We investigated this research question in a representative community cohort of 1500 participants. A questionnaire, comprising five domains of physical and emotional neglect, as well as physical, emotional, and sexual abuse, was used to assess...
全文获取路径: Elsevier  (合作)
影响因子:4.59 (2012)

  • 群落 开始
  • psychotic 精神病患者
  • trauma 外伤
  • psychosis 精神病
  • subclinical 亚临床的
  • stress 应力
  • sensitivity 灵敏度
  • onset 开始
  • community 开始
  • effect 效应
  • sectional 部分的