Immunomodulatory effects and anti- Candida activity of lactobacilli in macrophages and in invertebrate model of Galleria mellonella
作者: Felipe Eduardo de OliveiraRodnei Dennis RossoniPatricia Pimentel de BarrosBarbara Evelyn BegniniJuliana Campos JunqueiraAntonio Olavo Cardoso JorgeMariella Vieira Pereira LeãoLuciane Dias de Oliveira
作者单位: 1Department of Biosciences and Oral Diagnosis, São Paulo State University (Unesp), Institute of Science and Technology, São José dos Campos, Avenida Engenheiro Francisco José Longo 777, São Dimas, CEP: 12245-000, São Paulo, Brazil
2Institute of Basic Biosciences, School of Medicine, University of Taubaté, Av. Tiradentes, 500, Centro, Taubaté, CEP: 12030-180, São Paulo, Brazil
刊名: Microbial Pathogenesis, 2017, Vol.110 , pp.603-611
来源数据库: Elsevier Journal
DOI: 10.1016/j.micpath.2017.08.006
关键词: ProbioticLactic acid bacteriaLactobacillusYeastsMacrophagesMycology
英文摘要: Abstract(#br)Due to the growing number of multi-resistant Candida spp., adjuvant treatments that may help combat these fungal pathogens are relevant and useful. This study evaluated the immunomodulation and anti- Candida activity of Lactobacillus rhamnosus (LR), Lactobacillus acidophilus and Lactobacillus paracasei suspensions, either single- or multiple-strain, in mouse macrophages (RAW 264.7) and Galleria mellonella (GM). Mouse macrophages were activated by different lactobacilli suspensions and challenged with C. albicans (CA). Tumor necrosis factor (TNF)-α, interleukin IL-1β, IL-6 and IL-17 production and cell viability were investigated. LR was the best suspension for stimulating all evaluated cytokines and thus was used in subsequent in vivo assays. Two C. albicans clinical strains,...
全文获取路径: Elsevier  (合作)
影响因子:1.974 (2012)

  • invertebrate 无脊椎动物
  • Candida 坎迪德
  • macrophages 巨噬细胞
  • activity 活度
  • effects 海员自身物品
  • model 模型