Rheumatoid arthritis and risk of chronic obstructive pulmonary disease or asthma among women: A marginal structural model analysis in the Nurses’ Health Study
作者: Jeffrey A. SparksTzu-Chieh LinCarlos A. CamargoMedha BarbhaiyaSara K. TedeschiKaren H. CostenbaderBenjamin A. RabyHyon K. ChoiElizabeth W. Karlson
作者单位: 1Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, Boston, MA
2Harvard Medical School, Boston, MA
3Harvard T.H. Chan School of Public Health, Boston, MA
4Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA
5Channing Division of Network Medicine, Brigham and Women’s Hospital, Boston, MA
6Division of Rheumatology, Massachusetts General Hospital, Boston, MA
刊名: Seminars in Arthritis and Rheumatism, 2018, Vol.47 (5), pp.639-648
来源数据库: Elsevier Journal
DOI: 10.1016/j.semarthrit.2017.09.005
关键词: Rheumatoid arthritisEpidemiologyCausal inferenceCOPDAsthmaRespiratory
原始语种摘要: Abstract(#br)Objective(#br)We investigated whether RA increases risk for chronic obstructive pulmonary disease (COPD) or asthma independent of factors occurring before RA onset or mediating these respiratory morbidities after diagnosis, such as cigarette smoking.(#br)Methods(#br)Within the prospective Nurses’ Health Study ( n = 121,701 women; 1976–2014), we identified an incident RA cohort and matched each woman with RA to 10 comparators without RA by age and year at index date of RA diagnosis, excluding women with COPD or asthma at baseline. Data were obtained through biennial questionnaires and medical records. We used marginal structural models to determine the independent effect of RA on incident COPD or asthma adjusting for confounders and time-varying mediators through inverse...
全文获取路径: Elsevier  (合作)
影响因子:3.806 (2012)

  • asthma 哮喘
  • obstructive 阻碍的
  • arthritis 关节炎
  • chronic 延续很长的
  • structural 构造
  • pulmonary 肺的
  • increased 增加
  • seropositive 血清反应阳性的
  • associated 相关的
  • smoking 抽烟