Familial liability to psychosis is a risk factor for multimorbidity in people with psychotic disorders and their unaffected siblings
作者: M.A. IslamM.F.H. KhanP.J. QueeH. SniederE.R. van den HeuvelR. BruggemanB.Z. AlizadehA.A. Bartels-VelthuisN.J. van BeverenW. CahnL. de HaanP. DelespaulC.J. MeijerI. Myin-GermeysR.S. KahnF. SchirmbeckC.J.P. SimonsN.E. van HarenJ. van OsR. van Winkel
作者单位: 1University of Groningen, University Medical Center Groningen, University Center for Psychiatry, Groningen, The Netherlands
2Antes Center for Mental Health Care, Rotterdam, The Netherlands
3Erasmus MC, Department of Psychiatry, Rotterdam, The Netherlands
4Erasmus MC, Department of Neuroscience, Rotterdam, The Netherlands
5University Medical Center Utrecht, Department of Psychiatry, Brain Centre Rudolf Magnus, Utrecht, The Netherlands
6Academic Medical Center, University of Amsterdam, Department of Psychiatry, Amsterdam, The Netherlands
7Maastricht University Medical Center, Department of Psychiatry and Psychology, School for Mental Health and Neuroscience, Maastricht, The Netherlands
8KU Leuven, Department of Neuroscience, Research Group Psychiatry, Center for Contextual Psychiatry, Leuven, Belgium
9GGzE, Institute for Mental Health Care Eindhoven and De Kempen, Eindhoven, The Netherlands
10King's College London, King's Health Partners, Department of Psychosis Studies, Institute of Psychiatry, London, United Ki
刊名: European Psychiatry, 2017, Vol.45 , pp.81-89
来源数据库: Elsevier Journal
DOI: 10.1016/j.eurpsy.2017.05.001
关键词: Familial liabilityMultimorbidityPhysical healthPsychosisSchizophrenia
原始语种摘要: Abstract(#br)Background(#br)Multimorbidity may impose an overwhelming burden on patients with psychosis and is affected by gender and age. Our aim is to study the independent role of familial liability to psychosis as a risk factor for multimorbidity.(#br)Methods(#br)We performed the study within the framework of the Genetic Risk and Outcome of Psychosis (GROUP) project. Overall, we compared 1024 psychotic patients, 994 unaffected siblings and 566 controls on the prevalence of 125 lifetime diseases, and 19 self-reported somatic complaints. Multimorbidity was defined as the presence of two or more complaints/diseases in the same individual. Generalized linear mixed model (GLMM) were used to investigate the effects of gender, age (adolescent, young, older) and familial liability (patients,...
全文获取路径: Elsevier  (合作)
影响因子:3.285 (2012)

  • 较大地 精神病的
  • psychosis 精神病
  • unaffected 末触动的
  • psychotic 精神病患者
  • liability 责任
  • gender 性别
  • controls 控制机构
  • psychiatric 精神病的
  • significantly 精神病的
  • their 他们的
  • somatic 躯体的