Genomic epidemiology of methicillin-susceptible Staphylococcus aureus across colonisation and skin and soft tissue infection
作者: Alex GrinbergPatrick J. BiggsJi ZhangStephen RitchieZachary OneroaCharlotte O'NeillAli KarkabaNiluka S. VelathanthiriGeoffrey W. Coombs
作者单位: 1Massey University, Institute of Veterinary, Animal and Biomedical Sciences, Private Bag 11,222, Palmerston North, 4442, New Zealand
2University of Auckland, Faculty of Medical and Health Sciences, Molecular Medicine and Pathology, 85 Park Rd, Grafton, Auckland, 1023, New Zealand
3School of Veterinary and Life Sciences, Murdoch University, 90 South Street, Murdoch, WA, Australia
刊名: Journal of Infection, 2017
来源数据库: Elsevier Journal
DOI: 10.1016/j.jinf.2017.07.010
关键词: Staphylococcus aureusSkin and soft tissue infectionSSTIWhole genome sequencingZoonosesPets
原始语种摘要: Summary(#br)Objectives(#br)Staphylococcus aureus skin and soft tissue infection (Sa-SSTI) places a significant burden on healthcare systems. New Zealand has a high incidence of Sa-SSTI, and here most morbidity is caused by a polyclonal methicillin-susceptible (MSSA) bacterial population. However, MSSA also colonise asymptomatically the cornified epithelia of approximately 20% of the population, and their divide between commensalism and pathogenicity is poorly understood. We aimed to see whether MSSA are genetically differentiated across colonisation and SSTI; and given the close interactions between people and pets, whether strains isolated from pets differ from human strains.(#br)Methods(#br)We compared the genomes of contemporaneous colonisation and clinical MSSA isolates obtained in...
全文获取路径: Elsevier  (合作)
影响因子:4.073 (2012)

  • methicillin 6二甲氧基苯青霉素
  • infection 感染
  • epidemiology 列病学
  • tissue 组织
  • susceptible 敏感
  • across 横过