Cytotoxicity and genotoxicity of thymol verified in murine macrophages (RAW 264.7) after antimicrobial analysis in Candida albicans , Staphylococcus aureus , and Streptococcus mutans
作者: Kely Karina BelatoJonatas Rafael de OliveiraFernanda Saraiva de OliveiraLuciane Dias de OliveiraSamira Esteves Afonso Camargo
作者单位: 1São Paulo State University (UNESP), Institute of Science and Technology, Department of Biosciences and Oral Diagnosis, Av. Engenheiro Francisco José Longo, 777 – Jardim São Dimas, São José dos Campos, SP CEP 12245-000, Brazil
刊名: Journal of Functional Foods, 2018, Vol.40 , pp.455-460
来源数据库: Elsevier Journal
DOI: 10.1016/j.jff.2017.11.035
关键词: ThymolAntimicrobial activityCytotoxicityGenotoxicityTNF-α
英文摘要: Abstract(#br)Thymol is a phytocompound present in many plants and several biological effects have been reported, such as antimicrobial effect. However, the biocompatibility of this plant product should be checked. Thereby, the action of thymol was evaluated in C. albicans , S. aureus , and S. mutans , as well as in murine macrophages (RAW 264.7). Firstly, the effect of thymol was analyzed in planktonic cultures of microorganisms and the most effective concentration was evaluated in biofilms. Cytotoxicity, quantification of TNF-α and genotoxicity were checked. The results were analyzed by T-Test or ANOVA and Tukey's Test ( P ≤ .05). Thymol provided inhibitory and microbicidal effects for planktonic cultures and reduction of biofilms. High concentrations affected the viability of RAW 264.7....
全文获取路径: Elsevier  (合作)
影响因子:2.632 (2012)

  • antimicrobial 杀菌剂
  • genotoxicity 生殖毒性
  • thymol 百里酚
  • albicans 白的
  • murine 鼠灰色
  • macrophages 巨噬细胞
  • Candida 坎迪德
  • after 在之后
  • analysis 分析
  • activity 活度