Evaluation of the toxic effects of celecoxib on Xenopus embryo development
作者: Yeon-Hee YoonJi Yoon KimYong Chul BaeSung-Wook NamHee-Jung ChoSuho LeeHo Young ChungHyun-Shik LeeMae-Ja Park
作者单位: 1Department of Anatomy, Kyungpook National University, Daegu 41944, South Korea
2Pediatrics, Kyungpook National University, Daegu 41944, South Korea
3Molecular Medicine, Kyungpook National University, Daegu 41944, South Korea
4General Surgery, School of Medicine, Kyungpook National University, Daegu 41944, South Korea
5Department of Oral Anatomy, School of Dentistry, Kyungpook National University, Daegu 41944, South Korea
6School of Life Science, Kyungpook National University, Daegu 41944, South Korea
7Department of Surgery, Uijeongbu St. Mary's Hospital, The Catholic University of Korea #271, Cheonbo-ro, Uijeongbu-City, Gyenggi-Do 480-717, South Korea
刊名: Biochemical and Biophysical Research Communications, 2018, Vol.501 (2), pp.329-335
来源数据库: Elsevier Journal
DOI: 10.1016/j.bbrc.2018.03.002
关键词: CelecoxibTeratogenicityXenopus laevisFETAXVessel formation
英文摘要: Abstract(#br)Celecoxib is a non-steroidal anti-inflammatory drug that selectively inhibits cyclooxygenase-2 and is prescribed for severe pain and inflammation. The excellent therapeutic effects of celecoxib mean that it is frequently used clinically, including for women of child-bearing age. However, the prenatal effects of this compound have not been studied extensively in vertebrates. The present study examined the developmental toxicity of celecoxib using a frog embryo teratogenic assay- Xenopus (FETAX). In addition, we examined its effects on cell migration using co-cultures of human umbilical vein endothelial cells and 10T1/2 cells. These studies revealed that celecoxib induced concentration-dependent mortality and various malformations of the Xenopus internal organs, including gut...
全文获取路径: Elsevier  (合作)
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关键词翻译
关键词翻译
  • development 开发
  • effects 海员自身物品
  • embryo 
  • toxic 有毒的