Successful heart transplantation after desensitization in a patient with extremely high panel-reactive antibody levels and pre-transplant donor-specific antibody: a case report
作者: Yuki NakamuraDaisuke YoshiokaShigeru MiyagawaYasushi YoshikawaHiroki HataRyohei MatsuuraKoichi TodaYoshiki Sawa
作者单位: 1Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, 2-15 Yamada-Oka, Suita City, Osaka 565-0871, Japan
刊名: Transplantation Proceedings, 2018
来源数据库: Elsevier Journal
DOI: 10.1016/j.transproceed.2018.08.058
英文摘要: Abstract(#br)Elevated panel-reactive antibody (PRA) levels serve as a significant risk factor for allograft survival and episodes of rejection after heart transplantation (HTX). Patients with high PRA levels tend to show expressions of donor-specific human leukocyte antigen (HLA) antibodies (DSA), which can cause catastrophic hyperacute rejection after HTX. Therefore, such highly sensitized patients are required to undergo strategic perioperative desensitization therapy. We describe a successful HTX after desensitization in a patient with extremely high PRA levels and pre-transplant DSA positivity.
全文获取路径: Elsevier  (合作)
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来源刊物:
影响因子:0.952 (2012)

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关键词翻译
关键词翻译
  • antibody 抗体
  • donor 给予体
  • reactive 电抗的
  • patient 有耐性的
  • transplant 移植体
  • panel 
  • specific 
  • extremely 极端
  • heart 心脏
  • after 在之后