Single-nucleotide polymorphisms and haplotypes in the adiponectin gene contribute to the genetic risk for type 2 diabetes in Tunisian Arabs
作者: Nabil MtiraouiIntissar EzzidiAmira TurkiArbi ChaiebTouhami MahjoubWassim Y. Almawi
作者单位: 1Research Unit of Biology and Genetics of Cancer and Haematological and Autoimmune diseases, Faculty of Pharmacy of Monastir, University of Monastir, Monastir, Tunisia
2Higher Institute of Biotechnology of Monastir, University of Monastir, Tunisia
3Endocrinology and Diabetic Service, CHU Farhat Hached of Sousse, Tunisia
4Department of Medical Biochemistry, College of Medicine & Medical Sciences, Arabian Gulf University, P. O. Box 22979, Manama, Bahrain
刊名: Diabetes Research and Clinical Practice, 2012, Vol.97 (2), pp.290-297
来源数据库: Elsevier Journal
DOI: 10.1016/j.diabres.2012.02.015
关键词: AdiponectinAlleleHaplotypeTunisiaType 2 diabetes
原始语种摘要: Abstract(#br)Adiponectin is an adipocyte-produced protein involved in regulating glucose, lipid, and energy metabolism, and is encoded by ADIPOQ ( APM1 ) gene. ADIPOQ polymorphisms were previously associated with type 2 diabetes (T2DM) in Caucasian and non-Caucasian populations. We investigated the contribution of 13 polymorphisms in the promoter, coding regions, and 3′untranslated region of ADIPOQ gene to T2DM in 917 patients and 748 normoglycemic control subjects. ADIPOQ genotyping was done by allelic discrimination method. Of the 13 ADIPOQ variants analyzed, higher minor allele frequency of rs16861194 ( P <0.001), rs17300539 ( P <0.001), rs266729 ( P <0.001), rs822396 ( P...
全文获取路径: Elsevier  (合作)
影响因子:2.741 (2012)

  • nucleotide 核苷酸
  • genetic 遗传的
  • diabetes 糖尿病
  • association 联合
  • region 地域
  • normoglycemic 血糖量正常的
  • associated 相关的
  • haplotype 单倍体型
  • contribute 贡献
  • dominant 优势的