Prenatal ambient air pollution exposure, infant growth and placental mitochondrial DNA content in the INMA birth cohort
作者: Diana B.P. ClementeMaribel CasasBram G. JanssenAitana LertxundiLoreto Santa-MarinaCarmen IñiguezSabrina LlopJordi SunyerMònica GuxensTim S. NawrotMartine Vrijheid
作者单位: 1ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain
2Center for Environmental Sciences, Hasselt University, Diepenbeek, Belgium
3Universitat Pompeu Fabra, Barcelona, Spain
4CIBER de Epidemiologia y Salud Pública (CIBERESP), Institute of Health Carlos III, Madrid, Spain
5Universidad del País Vasco UPV-EUH, Spain
6Health Research Institute, Biodonostia, San Sebastián, Spain
7Public Health Division of Gipuzkoa, Basque Government, Spain
8Foundation for the Promotion of Health and Biomedical Research in the Valencian Region (FISABIO), Valencia, Spain
9University of Valencia, Valencia, Spain
10Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Centre – Sophia Children's Hospital, Rotterdam, The Netherlands
11Department of Public Health & Primary Care, Unit Environment & Health, Leuven University, Leuven, Belgium
刊名: Environmental Research, 2017, Vol.157 , pp.96-102
来源数据库: Elsevier Journal
DOI: 10.1016/j.envres.2017.05.018
关键词: Prenatal air pollutionNitrogen dioxideInfant growthMitochondrial DNA contentMediation
原始语种摘要: Abstract(#br)Background(#br)The association between prenatal air pollution exposure and postnatal growth has hardly been explored. Mitochondrial DNA (mtDNA), as a marker of oxidative stress, and growth at birth can play an intermediate role in this association.(#br)Objective(#br)In a subset of the Spanish birth cohort INMA we assessed first whether prenatal nitrogen dioxide (NO 2 ) exposure is associated with infant growth. Secondly, we evaluated whether growth at birth (length and weight) could play a mediating role in this association. Finally, the mediation role of placental mitochondrial DNA content in this association was assessed.(#br)Methods(#br)In 336 INMA children, relative placental mtDNA content was measured. Land-use regression models were used to estimate prenatal NO 2...
全文获取路径: Elsevier  (合作)
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影响因子:3.238 (2012)

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关键词翻译
关键词翻译
  • placental 胎盘的
  • exposure 暴露
  • prenatal 产前的
  • growth 生长
  • infant 幼儿
  • trimester 三个月时间
  • content 品位
  • pollution 污染
  • Infant 伊洛魁夜间战斗机和夜间跟踪系统
  • birth 出生