C-reactive protein inhibits high-molecular-weight adiponectin expression in 3T3-L1 adipocytes via PI3K/Akt pathway
作者: Yuanxin LiuCuiping LiuChao JiangSu WangQichao YangDan JiangGuoyue Yuan
作者单位: 1Department of Endocrinology, The Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China
2Public Laboratory Platform, First Affiliated Hospital of Najing Medical University, Nanjing 210029, China
刊名: Biochemical and Biophysical Research Communications, 2016, Vol.472 (1), pp.19-25
来源数据库: Elsevier Journal
DOI: 10.1016/j.bbrc.2016.01.143
英文摘要: Abstract(#br)Adiponectin, an adipose-specific protein hormone, is secreted from white adipose tissue and involved in glucose and lipid metabolism. It is assembled into low-molecular-weight trimer (LMW), middle-molecular-weight hexameric (MMW) and high-molecular-weight (HMW), among which HMW exhibits higher activity. In this study, we proved that C-reactive protein (CRP), an inflammatory marker, inhibited adiponectin expression, especially HMW in time-and dose-dependent manners. Furthermore, CRP decreased the HMW/total adiponectin ration and reduced adiponectin assembly by increasing ERp44, and decreasing Ero1-α and DsbA-L. CRP activated pAkt, the downstream of PI3K. Inhibition of PI3K or pAkt abolished the effect of CRP. Our study suggested that CRP decreased adiponectin expression and...
全文获取路径: Elsevier  (合作)

  • weight 
  • molecular 分子的
  • protein 蛋白质
  • expression 表示
  • pathway 轨道
  • reactive 电抗的