Activity of ceftolozane-tazobactam against Gram-negative pathogens isolated from lower respiratory tract infections in the Asia-Pacific region: SMART 2015-2016
作者: Shu-Chen KuoChun-Eng LiuPo-Liang LuYao-Shen ChenMin-Chi LuWen-Chien KoPo-Ren HsuehYin-Ching ChuangFu-Der Wang
作者单位: 1National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Zhunan, Taiwan
2Division of Infectious Disease, Department of Internal Medicine, Changhua Christian Hospital, Changhua, Taiwan
3Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
4College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
5School of Medicine, National Yang-Ming University, Taipei, Taiwan
6Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan
7Department of Microbiology and Immunology, School of Medicine, China Medical University, Taichung, Taiwan
8Department of Internal Medicine, National Cheng Kung University Medical College and Hospital, Tainan, Taiwan
9Department of Laboratory Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan
10Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiw
刊名: International Journal of Antimicrobial Agents, 2020, Vol.55 (3)
来源数据库: Elsevier Journal
DOI: 10.1016/j.ijantimicag.2020.105883
关键词: SusceptibilityCeftolozane/tazobactamLower respiratory tract infectionsGram-negative pathogenAsia-Pacific region
原始语种摘要: Abstract(#br)The aim of this study was to investigate the susceptibility of respiratory Gram-negative bacteria to ceftolozane/tazobactam and other antibiotics in the Asia-Pacific region during 2015-2016. MICs were determined using the CLSI standard broth microdilution method and interpreted accordingly. Pseudomonas aeruginosa (1574 isolates) , Klebsiella pneumoniae (1226) , Acinetobacter baumannii (627) and Escherichia coli (476) accounted for 73.1% of 5342 Gram-negative respiratory pathogens. Susceptibility to ceftolozane/tazobactam of individual Enterobacteriaceae was >80%, except for Enterobacter cloacae (76.6%) . Ceftolozane/tazobactam inhibited 81.9% of K. pneumoniae and 91.9% of E. coli , with respective MIC 50 /MIC 90 values of 0.5/>32 and 0.25/2 mg/L. For carbapenem-susceptible,...
全文获取路径: Elsevier  (合作)
影响因子:4.415 (2012)

  • carbapenem 氨基甲酰
  • respiratory 呼吸过程
  • susceptibility 磁化率
  • isolates 单离体
  • against 反对
  • Pacific 太平洋
  • region 地域
  • amikacin 丁胺卡那霉素
  • colistin 粘菌素
  • respective 分别