An ortho dimer of butylated hydroxyanisole inhibits nuclear factor kappa B activation and gene expression of inflammatory cytokines in macrophages stimulated by Porphyromonas gingivalis fimbriae
作者: Yukio MurakamiMasao ShojiAtsushi HirataShoji TanakaShigemasa HanazawaIchiro YokoeSeiichiro Fujisawa
作者单位: 1Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry, 1-1 Keyakidai, Sakado City, Saitama 350-0283, Japan
2Department of Applied Biological Science, College of Bioresource Science, Nihon University, 1866 Kameino, Fujisawa City, Kanagawa 252-8510, Japan
3Faculty of Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado City, Saitama 350-0295, Japan
刊名: Archives of Biochemistry and Biophysics, 2006, Vol.449 (1), pp.171-177
来源数据库: Elsevier Journal
DOI: 10.1016/
关键词: Butylated hydroxyanisolebis-BHAPorphyromonas gingivalis fimbriaeAnti-inflammatory activityNF-κBInflammatory cytokineMacrophage
英文摘要: Abstract(#br)Butylated hydroxyanisole, BHA, is widely used as a potent antioxidant, but its adverse effects such as carcinogenesis and proinflammatory activity have been reported, which are possibly due to the prooxidant property of this compound. We recently demonstrated that the dimer of 2-methoxyphenols exhibits cyclooxygenase-2 inhibition, because of lessening of its prooxidant property caused by the dimerization. In the present study, toward our goal of developing a chemopreventive agent for chronic periodontal diseases, we examined whether 2-BHA (2- tert -butyl-4-methoxyphenol) and its synthetic ortho dimer, bis-BHA (3,3′-di- tert -butyl-5,5′-dimethoxy-1,1′-biphenyl-2,2′-diol) could inhibit the Porphyromonas gingivalis fimbria-stimulated inflammatory reaction. The fimbria-induced...
全文获取路径: Elsevier  (合作)
影响因子:3.37 (2012)

  • 二聚物 巨噬细胞
  • ortho 垂直
  • butylated 丁基化的
  • stimulated 受激
  • inflammatory 激怒的
  • activation 活化
  • cytokines 细胞浆移动
  • nuclear 原子核的
  • macrophages 巨噬细胞
  • dimer 巨噬细胞
  • kappa k曲线