Nanostructured lipid systems modified with waste material of propolis for wound healing: Design, in vitro and in vivo evaluation
作者: Hélen Cássia RossetoLucas de Alcântara Sica de ToledoLizziane Maria Belloto de FranciscoElisabetta EspositoYunsook LimGiuseppe ValacchiRita CortesiMarcos Luciano Bruschi
作者单位: 1Postgraduate Program in Pharmaceutical Sciences, Laboratory of Research and Development of Drug Delivery Systems, Department of Pharmacy, State University of Maringa, Maringa, Parana, Brazil
2Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy
3Department of Food and Nutrition, Kyung Hee University, Seoul, South Korea
4Animal Science Department, Plants for Human Health Institute, NC Research Campus, NC State University, Kannapolis, USA
刊名: Colloids and Surfaces B: Biointerfaces, 2017, Vol.158 , pp.441-452
来源数据库: Elsevier Journal
DOI: 10.1016/j.colsurfb.2017.07.029
关键词: NanotechnologyMaterials scienceFormulationPropolis by-productNanoparticlesNanostructured lipid carriersPropolis byproduct
原始语种摘要: Abstract(#br)Propolis, a natural compound that can accelerate the wound healing process, is mainly used as ethanolic extract. The extractive solution may also be obtained from the propolis by-product (BP), transforming this waste material into a pharmaceutical active ingredient. Even if propolis does not show toxicity, when used as an extract over harmed skin or mucosa, the present ethanol content may be harmful to the tissue recovering, besides hindering the drug release. This study describes the development of solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) as topical propolis delivery systems and the investigation of their in vitro and in vivo activities. The extracts were evaluated to guarantee their quality, and the lipid dispersions were characterized with...
全文获取路径: Elsevier  (合作)
影响因子:3.554 (2012)

  • propolis 蜂巢腊胶
  • extracts 摘记
  • lipid 脂质
  • healing 加硫
  • material 充填料
  • vitro 体外
  • accelerate 促进
  • occlusive 闭合的
  • topical 局部的
  • waste 岩屑