Clinical and pathological predictors of recurrence in breast cancer patients achieving pathological complete response to neoadjuvant chemotherapy
作者: Mariko AsaokaKazutaka NaruiNobuyasu SuganumaTakashi ChishimaAkimitsu YamadaSadatoshi SugaeSaori KawaiNatsuki UenakaSaeko TeraokaKana MiyaharaTakahiko KawateEichi SatoToshitaka NagaoYuka MatsubaraShipra GandhiKazuaki TakabeTakashi Ishikawa
作者单位: 1Department of Breast Oncology and Surgery, Tokyo Medical University Hospital, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan
2Department of Pathology, Institute of Medical Science (Medical Research Center, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan
3Department of Breast and Thyroid Surgery, Yokohama City University Medical Center, 4-57 Urafune, Minami-ku, Yokohama, Kanagawa, 232-0024, Japan
4Department of Mammary Gland Endocrine Surgery, Kanagawa Cancer Center, 2-3-2 Nakano, Asahi-ku, Yokohama, Kanagawa, 241-8515, Japan
5Department of Breast Surgery, Yokohama Rosai Hospital, 3211 Kozukue-Chō, Kōhoku-Ku, Yokohama, Kanagawa, 222-0036, Japan
6Department of Gastroenterological Surgery, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa, 236-0004, Japan
7Division of Breast Medicine, Department of Medicine, Roswell Park Comprehensive Cancer Center, Elm & Carlton Streets, Buffalo, NY, 14263, USA
8Department of Surgical Oncology, Roswell Park Compr
刊名: European Journal of Surgical Oncology, 2019, Vol.45 (12), pp.2289-2294
来源数据库: Elsevier Journal
DOI: 10.1016/j.ejso.2019.08.001
关键词: Breast cancerNeoadjuvant chemotherapyPathological complete responseTumor recurrence
英文摘要: Abstract(#br)Introduction(#br)Despite the excellent prognosis associated with pathological complete response (pCR) to neoadjuvant chemotherapy (NAC), some patients still develop recurrence. Here, we investigated the outcomes of breast cancer patients with pCR, as well as the clinical and pathological predictors of cancer recurrence in these patients.(#br)Materials and methods(#br)Of the 1599 breast cancer patients treated with NAC, we evaluated 394 patients who achieved pCR between January 2007 and December 2016. pCR was defined as no evidence of invasive cancer in breast. Residual in situ ductal and axillary lymph node diseases were not considered. We analyzed the outcomes using the Kaplan–Meier method. We assessed the association of clinical and pathological predictors with cancer...
全文获取路径: Elsevier  (合作)
影响因子:2.614 (2012)

  • pathological 病理学的
  • chemotherapy 化学疗法
  • breast 胸部
  • recurrence 循环
  • cancer 癌症
  • response 响应
  • complete 实行