The coxsackie and adenovirus receptor (CAR) is required for renal epithelial differentiation within the zebrafish pronephros
作者: Elisabeth RaschpergerEtienne P.A. NeveAnnika WernersonKjell HultenbyRalf F. PetterssonArindam Majumdar
作者单位: 1Ludwig Institute for Cancer Research, Karolinska Institutet, Stockholm, Sweden
2Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden
3Department of Laboratory Medicine, Division of Pathology, Karolinska Institute Karolinska University Hospital, Huddinge, Sweden
4Department of Pathology, Karolinska University Hospital/Huddinge, Karolinska Institutet, Stockholm, Sweden
5Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
刊名: Developmental Biology, 2007, Vol.313 (1), pp.455-464
来源数据库: Elsevier Journal
DOI: 10.1016/j.ydbio.2007.10.049
关键词: CXADRCARCTXZebrafishPronephrosPodocyteTubulogenesisMicrovillusTight junction
原始语种摘要: Abstract(#br)The coxsackie and adenovirus receptor (CAR) is a member of the immunoglobulin superfamily and a component of vertebrate tight junctions. CAR protein is widely expressed in fish and mammals in organs of epithelial origin suggesting possible functions in epithelial biology. In order to gain insight into its function, we knocked the CAR gene down in zebrafish using antisense morpholinos. We identified a requirement for CAR in the terminal differentiation of glomerular podocytes and pronephric tubular epithelia. Podocytes differentiate in CAR morphants but are not able to elaborate a regularly patterned architecture of foot processes. In the tubules, CAR was required for the apposition of plasma membranes from adjacent epithelial cells but did not appear to be necessary for the...
全文获取路径: Elsevier  (合作)
影响因子:3.868 (2012)

  • CAR CARriage-RETurn
  • required 必需
  • epithelial 上皮的
  • within 在以内
  • vertebrate 有脊椎的
  • adenovirus 腺病毒
  • renal 肾的
  • organs 男生殖器
  • pronephros 前肾
  • tubular 管状的