BF211, a derivative of bufalin, enhances the cytocidal effects in multiple myeloma cells by inhibiting the IL-6/JAK2/STAT3 pathway
作者: Xiao-yu WuFang TianMin-hui SuMin WuYue HuangLi-hong HuLiang JinXue-jun Zhu
作者单位: 1State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Screening, School of Life Science and Technology, China Pharmaceutical University, 24 Tongjia Xiang, Nanjing, Jiangsu 210009, China
2Department of Center Laboratory, Jiangsu Provincial Traditional Chinese Medical Hospital, Nanjing, Jiangsu Province, China
3Pharmacy Institute, Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China
4Division of Hematology, Department of Medicine, Jiangsu Provincial Traditional Chinese Medical Hospital, Nanjing, Jiangsu Province, China
刊名: International Immunopharmacology, 2018, Vol.64 , pp.24-32
来源数据库: Elsevier Journal
DOI: 10.1016/j.intimp.2018.08.016
关键词: BF211BufalinMultiple myelomaIL-6/JAK2/STAT3Apoptosis
英文摘要: Abstract(#br)Despite remarkable advances in multiple myeloma (MM) therapy, this condition remains incurable. BF211 is an active compound derived from bufalin, which is isolated from the Traditional Chinese Medicine, Chansu. In this study, we explored the cytotoxicity of BF211 in 20 tumor cell lines and discovered that the MM cell lines, ARP-1 and CAG, exhibited greater sensitivity to BF211. Compared with bufalin, BF211 induced a greater apoptotic effect and lower acute toxicity at nanomolar concentration. The IL-6/JAK2/STAT3 signaling pathway is essential to the progression and development of MM. We showed that exogenous IL-6 promoted MM cell proliferation in a dose-dependent manner and this effect was blocked by BF211. Furthermore, BF211 suppressed the phosphorylation of JAK2 and STAT3...
全文获取路径: Elsevier  (合作)
影响因子:2.417 (2012)

  • myeloma 骨髓瘤
  • cytocidal 杀细胞的
  • bufalin 蟾蜍精
  • inhibiting 抑制
  • pathway 轨道
  • STAT 静止的
  • derivative 衍生物
  • cells 麻风细胞
  • multiple 多次的
  • effects 海员自身物品