Down-Regulation of S100A8 is an Independent Predictor of PSA Recurrence in Prostate Cancer Treated by Radical Prostatectomy
作者: Sarah MinnerDominik HagerStefan SteurerDoris HöflmayerMaria Christina TsourlakisChristina Möller-KoopTill S ClauditzClaudia Hube-MaggAndreas M LuebkeRonald SimonGuido SauterCosima GöbelSören WeidemannPatrick LebokDavid DumChristoph FrauneJakob IzbickiEike BurandtThorsten SchlommHartwig HulandHans HeinzerAlexander HaeseMarkus GraefenAsmus Heumann
作者单位: 1Institute of Pathology, University Medical Center Hamburg-Eppendorf, Germany
2General, Visceral and Thoracic Surgery Department and Clinic, University Medical Center Hamburg-Eppendorf, Germany
3Department of Urology, Charité - Universitätsmedizin Berlin, Berlin, Germany
4Martini-Clinic, Prostate Cancer Center, University Medical Center Hamburg- Eppendorf, Germany
刊名: Neoplasia, 2019, Vol.21 (9), pp.872-881
来源数据库: Elsevier Journal
DOI: 10.1016/j.neo.2019.07.003
英文摘要: Abstract(#br)Dysregulation of S100A8 is described in many different human tumor types, but its role in prostate cancer is unknown. To evaluate the clinical relevance of S100A8 expression in prostate cancer, a tissue microarray containing 13,665 tumors was analyzed by immunohistochemistry. Cytoplasmic S100A8 staining was compared to prostate cancer phenotype, patient prognosis and molecular features including TMPRSS2:ERG fusion status and deletions of PTEN , 3p, 5q and 6q. S100A8 immunostaining was typically seen in normal prostate tissue but lost in 60% of 9786 interpretable prostate cancers. In the remaining tumors, S100A8 was considered weak in 17.9%, moderate in 17.8% and strong in 5.4% of cases. Loss of S100A8 expression was linked to advanced tumor stage, high Gleason grade, positive...
全文获取路径: Elsevier  (合作)
影响因子:5.47 (2012)

  • PSA 被保护的存储器地址
  • Cancer 巨蟹座