Garlic extract favorably modifies markers of endothelial function in obese patients –randomized double blind placebo-controlled nutritional intervention
作者: Monika SzulińskaMatylda Kręgielska-NarożnaJoanna ŚwiątekPaulina StyśBarbara Kuźnar-KamińskaHieronim JakubowskiJarosław WalkowiakPaweł Bogdański
作者单位: 1Department of Education and Treatment of Obesity and Metabolic Disorders, University of Medical Sciences in Poznań, Szamarzewskiego Str. 84, 60-569 Poznań, Poland
2Department of Pulmonology, Allergology and Respiratory Oncology, University of Medical Sciences in Poznań, Szamarzewskiego Str. 84, 60-569 Poznań, Poland
3Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers University, New Jersey Medical School, International Center for Public Health, 225 Warren Street, Newark, NJ 07103-3535, USA
4Department of Biochemistry and Biotechnology, University of Life Sciences, Dojazd Str. 11, 60-632 Poznan, Poland
5Department of Pediatric Gastroenterology and Metabolic Diseases, University of Medical Sciences in Poznań, Szpitalna Str. 27/33, 60-572 Poznań, Poland
刊名: Biomedicine & Pharmacotherapy, 2018, Vol.102 , pp.792-797
来源数据库: Elsevier Journal
DOI: 10.1016/j.biopha.2018.03.131
关键词: GarlicObesityInflammationEndothelium
原始语种摘要: Abstract(#br)Objective(#br)Garlic exerts a range of effects relevant to human health. However, its influence on the endothelium in obese individuals remains unknown. We aimed to determine the effects of garlic extract (GE) on arterial stiffness and markers of endothelial function.(#br)Methods(#br)Ninety-two subjects were enrolled in this study. The participants were randomly assigned to receive 400 mg of GE or placebo daily for 3 months. The arterial stiffness index (SI) and markers of endothelial function such as high-sensitivity C-reactive protein (hsCRP), cholesterol (total, LDL, HDL), triglycerides, and plasminogen activator inhibitor 1 (PAI-1), as well as total antioxidant status (TAS) were quantified at baseline and the end of study.(#br)Results(#br)At the end of study SI (p =...
全文获取路径: Elsevier  (合作)
影响因子:2.068 (2012)

  • favorably 顺利地
  • intervention 
  • controlled 受控
  • markers 时标
  • placebo 无效对照药
  • cholesterol 胆甾醇
  • stiffness 刚性
  • extract 提取
  • obese 肥胖的
  • plasminogen 胞浆素原