Application of microwave-irradiation technique in deglycosylation of ginsenosides for improving apoptosis induction in human melanoma SK-MEL-2 cells
作者: Pilju ChoiKwantae KimTaejung KimYoung-Tae ParkBong Geun SongMyoung-Sook ShinYong Ho KimGwi Seo HwangKi Sung KangJungyeob Ham
作者单位: 1Natural Products Research Institute, Korea Institute of Science and Technology, Gangneung 25451, Republic of Korea
2College of Korean Medicine, Gachon University, Seongnam 13120, Republic of Korea
3Advanced Institute of Nanotechnology (SAINT), Sungkyunkwan University, Suwon 16419, Republic of Korea
4Division of Bio-Medical Science and Technology, University of Science and Technology, Daejeon 34113, Republic of Korea
刊名: Bioorganic & Medicinal Chemistry Letters, 2019, Vol.29 (3), pp.400-405
来源数据库: Elsevier Journal
DOI: 10.1016/j.bmcl.2018.12.033
关键词: ApoptosisGinsengGinsenosideMelanomaMicrowave irradiation
英文摘要: Abstract(#br)To increase the contents of medicinally effective ginsenosides, we used high-temperature and high-pressure thermal processing of ginseng by exposing it to microwave irradiation. To determine the anti-melanoma effect, the malignant melanoma SK-MEL-2 cell line was treated with an extract of microwave-irradiated ginseng. Microwave irradiation caused changes in the ginsenoside contents: the amounts of ginsenosides Rg1, Re, Rb1, Rb2, Rc, and Rd were disappeared, while those of less polar ginsenosides, such as Rg3, Rg5, and Rk1, were increased. In particular, the contents of Rk1 and Rg5 markedly increased. Melanoma cells treated with the microwave-irradiated ginseng extract showed markedly increased cell death. The results indicate that the microwave-irradiated ginseng extract...
全文获取路径: Elsevier  (合作)
影响因子:2.338 (2012)

  • improving 改进
  • technique 技术
  • human 人的
  • irradiation 照射
  • microwave 微波
  • induction 诱发
  • melanoma 黑瘤
  • Application 应用
  • apoptosis 细胞死
  • cells 麻风细胞