Quantitative determination of carcinogenic mycotoxins in human and animal biological matrices and animal-derived foods using multi-mycotoxin and analyte-specific high performance liquid chromatography-tandem mass spectrometric methods
作者: Xiaoqin CaoXiaofei LiJian LiYunhui NiuLu ShiZhenfeng FangTao ZhangHong Ding
作者单位: 1College of Medicine, Jianghan University, Wuhan, 430056, People’s Republic of China
2Department of Pharmacy, Wuhan University, Wuhan, 430072, People’s Republic of China
刊名: Journal of Chromatography B, 2018, Vol.1073 , pp.191-200
来源数据库: Elsevier Journal
DOI: 10.1016/j.jchromb.2017.10.006
关键词: Carcinogenic mycotoxinsHuman blood and urineEdible animal tissuesMulti-mycotoxin analysisToxicokinetics
原始语种摘要: Abstract(#br)A sensitive and reliable multi-mycotoxin-based method was developed to identify and quantify several carcinogenic mycotoxins in human blood and urine, as well as edible animal tissues, including muscle and liver tissue from swine and chickens, using liquid chromatography–tandem mass spectrometry (LC–MS/MS). For the toxicokinetic studies with individual mycotoxins, highly sensitive analyte-specific LC–MS/MS methods were developed for rat plasma and urine. Sample purification consisted of a rapid ‘dilute and shoot’ approach in urine samples, a simple ‘dilute, evaporate and shoot’ approach in plasma samples and a ‘QuEChERS’ procedure in edible animal tissues. The multi-mycotoxin and analyte-specific methods were validated in-house: The limits of detection (LOD) for the...
全文获取路径: Elsevier  (合作)
影响因子:2.487 (2012)

  • mycotoxin 真菌毒素
  • animal 动物的
  • tandem 串联机
  • spectrometric 光谱测定的
  • determination 测定
  • carcinogenic 致癌的
  • analyte 分析物
  • specific 
  • exposure 暴露
  • liquid 液体