Evaluation of butylated hydroxyanisole, myo -inositol, curcumin, esculetin, resveratrol and lycopene as inhibitors of benzo[ a ]pyrene plus 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in A/J mice
作者: Stephen S HechtPatrick M.J KenneyMingyao WangNeil TrushinSanjiv AgarwalA Venket RaoPramod Upadhyaya
作者单位: 1University of Minnesota Cancer Center, Box 806 Mayo, 420 Delaware St. SE, Minneapolis, MN 55455, USA
2American Health Foundation, 1 Dana Road, Valhalla, NY 10595, USA
3Department of Nutritional Sciences, University of Toronto, 150 College St., Toronto, Ont. M5S1A8, Canada
刊名: Cancer Letters, 1999, Vol.137 (2), pp.123-130
来源数据库: Elsevier Journal
DOI: 10.1016/S0304-3835(98)00326-7
关键词: Butylated hydroxyanisolemyo -InositolCurcuminEsculetinResveratrolLycopeneBenzo[ a ]pyrene4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanoneChemoprevention
原始语种摘要: Abstract(#br)The potential activities of butylated hydroxyanisole (BHA), myo -inositol, curcumin, esculetin, resveratrol and lycopene-enriched tomato oleoresin (LTO) as chemopreventive agents against lung tumor induction in A/J mice by the tobacco smoke carcinogens benzo[ a ]pyrene (BaP) and 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK) were evaluated. Groups of 20 A/J mice were treated weekly by gavage with a mixture of BaP and NNK (3 μmol each) for 8 weeks, then sacrificed 26 weeks after the first carcinogen treatment. Mice treated with BHA (20 or 40 μmol) by gavage 2 h before each dose of BaP and NNK had significantly reduced lung tumor multiplicity. Treatment with BHA (20 or 40 μmol) by gavage weekly or with dietary BHA (2000 ppm), curcumin (2000 ppm) or resveratrol (500 ppm)...
全文获取路径: Elsevier  (合作)
影响因子:4.258 (2012)

  • esculetin 七叶亭
  • curcumin 姜黄色素
  • inositol 肌醇
  • pyridyl 氮苯基
  • myo 
  • resveratrol 白藜芦醇
  • butylated 丁基化的
  • butanone 丁酮
  • tumorigenesis 瘤形成
  • carcinogen 致癌物质