Hippo Cascade Controls Lineage Commitment of Liver Tumors in Mice and Humans
作者: Shanshan ZhangJingxiao WangHaichuan WangLingling FanBiao FanBilly ZengJunyan TaoXiaolei LiLi CheAntonio CiglianoSilvia RibbackFrank DombrowskiBin ChenWenming CongLixin WeiDiego F. CalvisiXin Chen
作者单位: 1Tumor Immunology and Gene Therapy Center, Second Military Medical University, Shanghai, China
2Department of Pathology, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China
3Department of Bioengineering and Therapeutic Sciences and Liver Center, University of California, San Francisco, California
4Department of Pediatrics, University of California, San Francisco, California
5Institute for Computational Health Sciences, University of California, San Francisco, California
6Second Clinical Medical School, Beijing University of Chinese Medicine, Beijing, China
7Liver Transplantation Division, Department of Liver Surgery, West China Hospital, Sichuan University, Chengdu, China
8Department of Gastrointestinal Surgery, Key Laboratory of Carcinogenesis and Translational Research, Peking University Cancer Hospital & Institute, Beijing, China
9National Institute of Gastroenterology “S. de Bellis”, Research Hospital, Castellana Grotte, Italy
10Institute of Pathology, University of G
刊名: The American Journal of Pathology, 2018, Vol.188 (4), pp.995-1006
来源数据库: Elsevier Journal
DOI: 10.1016/j.ajpath.2017.12.017
英文摘要: Primary liver cancer consists mainly of hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC). A subset of human HCCs expresses a ICC-like gene signature and is classified as ICC-like HCC. The Hippo pathway is a critical regulator of normal and malignant liver development. However, the precise function(s) of the Hippo cascade along liver carcinogenesis remain to be fully delineated. The role of the Hippo pathway in a murine mixed HCC/ICC model induced by activated forms of AKT and Ras oncogenes (AKT/Ras) was investigated. The authors demonstrated the inactivation of Hippo in AKT/Ras liver tumors leading to nuclear localization of Yap and TAZ. Coexpression of AKT/Ras with Lats2, which activates Hippo, or the dominant negative form of TEAD2 (dnTEAD2), which blocks Yap/TAZ...
全文获取路径: Elsevier  (合作)
影响因子:4.522 (2012)