Overexpression of α3/α5/β4 nicotinic receptor subunits modifies impulsive-like behavior
作者: Xavier ViñalsSusanna MolasXavier GallegoRubén D. Fernández-MontesPatricia RobledoMara DierssenRafael Maldonado
作者单位: 1Laboratory of Neuropharmacology, Pompeu Fabra University (UPF), PRBB, Calle Dr. Aiguader, 88, 08003 Barcelona, Spain
2Genes and Disease Program, Center for Genomic Regulation (CRG-UPF), PRBB and CIBERER, Barcelona, Spain
3Neuropsychopharmacology Research Program, IMIM (Hospital del Mar Research Institute), PRBB, Barcelona, Spain
刊名: Drug and Alcohol Dependence, 2012, Vol.122 (3), pp.247-252
来源数据库: Elsevier Journal
DOI: 10.1016/j.drugalcdep.2011.09.027
关键词: Nicotine dependenceGene variantsCHRNA3/A5/B4 gene clusterNicotine acetylcholine receptorDelayed alternation
原始语种摘要: Abstract(#br)Recent studies have revealed that sequence variants in genes encoding the α3/α5/β4 nicotinic acetylcholine receptor subunits are associated with nicotine dependence. In this study, we evaluated two specific aspects of executive functioning related to drug addiction (impulsivity and working memory) in transgenic mice over expressing α3/α5/β4 nicotinic receptor subunits. Impulsivity and working memory were evaluated in an operant delayed alternation task, where mice must inhibit responding between 2 and 8s in order to receive food reinforcement. Working memory was also evaluated in a spontaneous alternation task in an open field. Transgenic mice showed less impulsive-like behavior than wild-type controls, and this behavioral phenotype was related to the...
全文获取路径: Elsevier  (合作)
影响因子:3.141 (2012)

  • alternation 互层
  • receptor 接受体
  • nicotinic 烟碱酸的
  • impulsive 脉冲的
  • working 开采
  • dependence 从属
  • nicotine 尼古丁
  • acetylcholine 乙酰胆碱
  • memory 记忆
  • operant 工作的