Levetiracetam accumulation in renal failure causing myoclonic encephalopathy with triphasic waves
作者: Serge VulliemozPatricia IwanowskiTheodor LandisPierre Jallon
作者单位: 1EEG and Epilepsy Unit, University Hospital and Faculty of Medicine of Geneva, 24 rue Micheli-du-Crest, 1211 Geneva 14, Switzerland
2Neurology Department, University Hospital and Faculty of Medicine of Geneva, 24 rue Micheli-du-Crest, 1211 Geneva 14, Switzerland
刊名: Seizure: European Journal of Epilepsy, 2009, Vol.18 (5), pp.376-378
来源数据库: Elsevier Journal
DOI: 10.1016/j.seizure.2009.01.006
关键词: LevetiracetamTriphasic wavesMyoclonusIntoxicationRenal failure
原始语种摘要: Abstract(#br)Triphasic waves are seen in the electro-encephalogram of adult patients with toxic-metabolic encephalopathies of various origins. Levetiracetam is a broad spectrum anti-epileptic drug with renal elimination and no hepatic metabolism. We describe the case of encephalopathy with triphasic waves concomitant with levetiracetam accumulation in a patient with chronic renal failure. The condition was reversible after down-titration of levetiracetam with no change of the renal function. Other causes of metabolic encephalopathy were excluded. Moreover, this patient suffered from a probable cortical myoclonus that relapsed after cessation of the drug but was well controlled by a low dosage adapted to the renal failure. In cases of metabolic encephalopathy with triphasic waves in a...
全文获取路径: Elsevier  (合作)
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影响因子:2.004 (2012)

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关键词翻译
关键词翻译
  • encephalopathy 脑病
  • triphasic 三相的
  • myoclonic 肌阵挛的
  • renal 肾的
  • failure 破坏
  • accumulation 堆积
  • myoclonus 肌阵挛
  • epileptic 癫痫
  • encephalogram 脑 x 线照片
  • cessation 停止