DNA bending is induced by binding of the glucocorticoid receptor DNA binding domain and progesterone receptors to their response element
作者: Larry N. PetzAnn M. NardulliJongsook KimKathryn B. HorwitzLeonard P. FreedmanDavid J. Shapiro
作者单位: 1Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, U.S.A.
2Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, U.S.A.
3Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, U.S.A.
4Department of Pathology, University of Colorado Health Sciences Center, Denver, CO 80262, U.S.A.
5Cell Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, U.S.A.
刊名: Journal of Steroid Biochemistry and Molecular Biology, 1997, Vol.60 (1), pp.31-41
来源数据库: Elsevier Journal
DOI: 10.1016/S0960-0760(96)00171-9
原始语种摘要: Abstract(#br)Circular permutation analysis was used to determine the degree of DNA bending induced by binding of the glucocorticoid receptor (GR) DNA binding domain (DBD), the human progesterone receptor (PR) DBD, PR-A:A and PR-B:B homodimers, and PR-A:B heterodimers to the glucocorticoid response element/progesterone response element ( GRE PRE ). The bending angles induced by the GR DBD and the PR DBD were approximately 28° and 25°, respectively. The PR-B:B and PR-A:A homodimers and the PR-A:B heterodimers all induced similar DNA bending angles of 72–77°. The substantially greater DNA bend induced by full-length PR compared to the PR DBD indicates that sequences outside the classic zinc finger DNA binding domain may play an important role in the interaction of PR with the GRE PRE ....
全文获取路径: Elsevier  (合作)
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关键词翻译
关键词翻译
  • induced 感应的
  • binding 装订
  • glucocorticoid 糖皮质激素
  • receptor 接受体
  • progesterone 孕酮
  • bending 弯曲
  • DNA Deoxyribonucleic Acid
  • domain 领域
  • element 元素
  • response 响应