Proton magnetic resonance spectroscopy in pediatric obsessive–compulsive disorder: Longitudinal study before and after treatment
作者: Luisa LázaroNúria BargallóSusana AndrésCarles FalcónAstrid MorerCarme JunquéJosefina Castro-Fornieles
作者单位: 1Child and Adolescent Psychiatry and Psychology Department, Institute of Neurosciences, Hospital Clínic Universitari of Barcelona, Barcelona, Spain
2IDIBAPS (Institut d'Investigacions Biomèdiques August Pi i Sunyer), Spain
3Image Diagnostic Center, Hospital Clínic Universitari of Barcelona, Barcelona, Spain
4Department of Psychiatry and Clinical Psychobiology, Health Sciences Division, University of Barcelona, Barcelona, Spain
5Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Spain
6Centro de Investigación Nacional en Red en Bioingeniería, Biomateriales y Nanomedicina, CIBER-BBN, Barcelona, Spain
刊名: Psychiatry Research: Neuroimaging, 2012, Vol.201 (1), pp.17-24
来源数据库: Elsevier Journal
DOI: 10.1016/j.pscychresns.2011.01.017
关键词: Children and adolescentsMagnetic resonance spectroscopyObsessive–compulsive disorderTreatment naïve
原始语种摘要: Abstract(#br)Abnormalities in neurochemical compounds in obsessive–compulsive disorder (OCD) may help increase our knowledge of neurobiological abnormalities in the fronto-subcortical circuits. The aims of this exploratory study were to identify with in vivo magnetic resonance spectroscopy ( 1 H-MRS) the possible alterations in neurometabolites in a group of drug naïve children and adolescents with OCD in comparison with a control group and to determine whether there was any effect of treatment on the metabolite levels. Eleven OCD children and adolescents (age range 9–17years; 6 male, 5 female) and twelve healthy subjects with similar age, sex and estimated intellectual quotient were studied. Proton magnetic resonance spectroscopy at 1.5T was used. We...
全文获取路径: Elsevier  (合作)
影响因子:3.364 (2012)

  • resonance 共振
  • compulsive 强制的
  • spectroscopy 分光学
  • disorder 无序
  • magnetic 磁的
  • phosphocholine 胆碱磷酸
  • treatment 处理
  • frontal 额骨
  • cingulate 具带的
  • bilaterally 双向地