Phytosterol feeding induces alteration in testosterone metabolism in rat tissues
作者: Atif B AwadMaria Sri HartatiCarol S Fink
作者单位: 1Department of Physical Therapy, Exercise and Nutrition Sciences, State University of New York at Buffalo, Buffalo, NY USA
刊名: The Journal of Nutritional Biochemistry, 1998, Vol.9 (12), pp.712-717
来源数据库: Elsevier Journal
DOI: 10.1016/S0955-2863(98)00076-X
关键词: testosteroneprostate cancer5-α-reductasearomataseβ-sitosterolliverprostatetestis
原始语种摘要: Abstract(#br)The objective of the present study was to examine the metabolism of testosterone in rat tissues as influenced by dietary phytosterols. Testosterone metabolism includes reductions to more active metabolites or aromatization to estrogen. Both higher levels of androgens and estrogens are implicated as risk factors in the development of prostate cancer. Tissues studied included liver, testis, and prostate. Feeding 2% phytosterols with 0.2% cholic acid to rats for 22 days resulted in a 33% reduction in serum testosterone compared with controls, which received only 0.2% cholic acid in the diet. 5-α-Reductase was reduced by 41 to 44% and 33% in the liver and prostate, respectively. No effect of phytosterols was observed in the testis. Only aromatase activity of the prostate was...
全文获取路径: Elsevier  (合作)
影响因子:4.552 (2012)

  • testosterone 睾酮
  • prostate 前列腺
  • metabolism 代谢
  • aromatase 芳香酶
  • liver 
  • androgens 雄性激素
  • estrogen 雌激素
  • feeding 供给
  • sitosterol 谷甾醇
  • reduced 减缩的