Protective efficacy of a novel alpha hemolysin subunit vaccine (AT62) against Staphylococcus aureus skin and soft tissue infections
作者: Rajan P. AdhikariChristopher D. ThompsonM. Javad AmanJean C. Lee
作者单位: 1Integrated Biotherapeutics, Inc., Gaithersburg, MD, USA
2Division of Infectious Diseases, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA
刊名: Vaccine, 2016
来源数据库: Elsevier Journal
DOI: 10.1016/j.vaccine.2016.09.061
关键词: Staphylococcus aureusAlpha hemolysinVaccineSkin and soft tissue infectionMouse infection models
英文摘要: Abstract(#br)Alpha hemolysin (Hla) is a pore-forming toxin produced by most Staphylococcus aureus isolates. Hla is reported to play a key role in the pathogenesis of staphylococcal infections, such as skin and soft tissue infection, pneumonia, and lethal peritonitis. This study makes use of a novel recombinant subunit vaccine candidate (AT62) that was rationally designed based on the Hla heptameric crystal structure. AT62 comprises a critical structural domain at the N terminus of Hla, and it has no inherent toxic properties. We evaluated the efficacy of AT62 in protection against surgical wound infection and skin and soft tissue infection. Mice were vaccinated on days 0, 14, and 28 with 20μg AT62 or bovine serum albumin (BSA) mixed with Sigma adjuvant system®. Mice...
全文获取路径: Elsevier  (合作)
影响因子:3.492 (2012)

  • hemolysin 溶血素
  • against 反对
  • efficacy 效验
  • subunit 亚单位
  • alpha 接字母顺序的
  • novel 长篇小说
  • vaccine 菌苗
  • infection 感染
  • tissue 组织
  • Vaccine 疫苗程序