Lactobacillus paracasei 28.4 reduces in vitro hyphae formation of Candida albicans and prevents the filamentation in an experimental model of Caenorhabditis elegans
作者: Patrícia Pimentel de BarrosLiliana ScorzoniFelipe de Camargo RibeiroLuciana Ruano de Oliveira FugisakiBeth Burgwyn FuchsEleftherios MylonakisAntonio Olavo Cardoso JorgeJuliana Campos JunqueiraRodnei Dennis Rossoni
作者单位: 1Department of Biosciences and Oral Diagnosis, Institute of Science and Technology, UNESP – Univ Estadual Paulista, Francisco Jose Longo 777, Sao Dimas, Sao Jose dos Campos, CEP: 12245-000, SP, Brazil
2Division of Infectious Diseases, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, RI, 02903, USA
刊名: Microbial Pathogenesis, 2018, Vol.117 , pp.80-87
来源数据库: Elsevier Journal
DOI: 10.1016/j.micpath.2018.02.019
关键词: ProbioticsLactobacillusGene expressionPathogenesisYeastsCandida albicans
英文摘要: Abstract(#br)The objective of this study was to evaluate the influence of microbe-microbe interactions to identify a strain of Lactobacillus that could reduce the filamentation of Candida albicans ATCC 18804 using in vitro and in vivo models. Thus presenting a probiotic effect against the fungal pathogen. First, we analyzed the ability of 25 clinical isolates of Lactobacillus to reduce filamentation in C. albicans in vitro . We found that L. paracasei isolate 28.4 exhibited the greatest reduction of C. albicans hyphae ( p = 0.0109). This reduction was confirmed by scanning electron microscopy analysis. The influence of C. albicans filamentation was found to be contributed through reduced gene expression of filament associated genes ( TEC1 and UME6 ). In an in vivo study, prophylactic...
全文获取路径: Elsevier  (合作)
影响因子:1.974 (2012)

  • filamentation 成丝作用
  • formation 建造
  • Candida 坎迪德
  • albicans 白的
  • experimental 实验的
  • hyphae 菌丝
  • model 模型
  • vitro 体外