The embryo-placental CD15-positive “vasculogenic zones” as a source of propranolol-sensitive pediatric vascular tumors
作者: L. SeidmannL. AnspachW. Roth
作者单位: 1Institute of Pathology, University Medical Centre of the Johannes Gutenberg University, Mainz, Germany
刊名: Placenta, 2016, Vol.38 , pp.93-99
来源数据库: Elsevier Journal
DOI: 10.1016/j.placenta.2015.12.013
关键词: PlacentaVasculogenic zoneCD15Infantile hemangiomaCerebral cavernomapropranolol
原始语种摘要: Abstract(#br)Objective(#br)Propranolol-induced involution is a unique biological feature of some pediatric vascular tumors, for instance infantile hemangioma (IH), cerebral cavernoma or chorioangioma. Currently, the cellular origin of these distinct tumors is unclear. In this study, we tested the hypothesis that propranolol-responsive vascular tumors are derived from common vessel-forming CD15 + progenitor cells which occur in early gestation. The aim of this study was to identify the tumor-relevant CD15 + progenitors at the early stages of embryo-placental development.(#br)Materials and methods(#br)Human embryo-placental units of 4–8 weeks gestation and pediatric vascular tumors were tested for expression of the tumor-relevant markers CD15, CD31 and CD34.(#br)Results(#br)Placental...
全文获取路径: Elsevier  (合作)
影响因子:3.117 (2012)

  • propranolol 普萘洛尔
  • placental 胎盘的
  • pediatric 儿科的
  • vascular 维管的
  • embryo 
  • sensitive 灵敏的
  • positive 阳片
  • source