Platelet reactivity in patients receiving a maintenance dose of P2Y12-ADP receptor antagonists undergoing elective percutaneous coronary intervention
作者: Laurent BonelloMarc LaineFranck ThunyFranck PaganelliGilles LemesleAntoine RochFrançois KerbaulFrançoise Dignat-GeorgeJulie BerbisCorinne Frere
作者单位: 1Département de Cardiologie, Hôpital Universitaire Nord de Marseille, Assistance-Publique Hôpitaux de Marseille, Marseille, France
2Vascular Research Center of Marseille, INSERM UMR-S 1076, Aix-Marseille Université, Marseille, France
3MARS Cardio, Mediterranean Academic association for Research and Studies in Cardiology, Marseille, France
4Département de Cardiologie, Hôpital Universitaire de Lilles, Lilles, France
5Service d'accueil des Urgences, Assistance Publique-Hôpitaux de Marseille, Nord, Marseille, France
6UMR MD2, Aix-Marseille Université, Marseille, France
7Pole RUSH, Assistance Publique-Hôpitaux de Marseille, Marseille, France
8Department of Biostatistics, Aix-Marseille Université, Marseille, France
刊名: International Journal of Cardiology, 2016, Vol.216 , pp.190-193
来源数据库: Elsevier Journal
DOI: 10.1016/j.ijcard.2016.04.165
关键词: P2Y12-ADP receptorHigh on-treatment platelet reactivityMyocardial infarctionLoading dosePercutaneous coronary intervention
英文摘要: Abstract(#br)Background(#br)P2Y12-ADP receptor blockade during percutaneous coronary intervention (PCI) is critical to prevent thrombotic events. In patients under chronic P2Y12 blockers, the use of additional loading dose (LD) before an elective PCI is debated. We aimed to investigate the rate of high on-treatment platelet reactivity (HTPR) in patients undergoing elective PCI during chronic clopidogrel or ticagrelor therapy.(#br)Methods and results(#br)We performed a sub-group analysis of a randomized trial comparing ticagrelor and clopidogrel in acute coronary syndrome (ACS) patients undergoing PCI. Multi-vessel disease patients requiring a staged PCI one month after the ACS were included. The VASP (vasodilatatory phosphoprotein) index, which is a specific and reproducible platelet...
全文获取路径: Elsevier  (合作)
影响因子:5.509 (2012)

  • intervention 
  • reactivity 反应性
  • coronary 冠状的
  • receptor 接受体
  • elective 选择的
  • receiving 接收
  • percutaneous 经皮的
  • infarction 梗塞
  • ADP Acceptance Data Package
  • maintenance 维持