Anti-tumor mechanism of eicosapentaenoic acid (EPA) on ovarian tumor model by improving the immunomodulatory activity in F344 rats
作者: Nana BieLirong HanMeng MengYuanyuan ZhangMingzhu GuoChunling Wang
作者单位: 1State Key Laboratory of Food Nutrition and Safety, Key Laboratory of Food Nutrition and Safety, Ministry of Education, College of Food Engineering and Biotechnology, Tianjin University of Science and Technology, No. 29, 13th Avenue, Tianjin Economy Technological Development Area, Tianjin 300457, People’s Republic of China
2College of Public Health, Hebei University, No. 342 Yuhuadonglu, Baoding 071000, China
刊名: Journal of Functional Foods, 2019
来源数据库: Elsevier Journal
DOI: 10.1016/j.jff.2019.103739
关键词: Eicosapentaenoic acidOvarian tumorImmunomodulatory activityMacrophages
英文摘要: Abstract(#br)Eicosapentaenoic acid (EPA) has been known to induce human ovarian cancer cells apoptosis in vitro . However, the anti-tumor mechanisms of EPA in vivo have been rarely reported. In this study, the effect of EPA on the ovarian cancer rat model and its related mechanism were investigated. The results showed after EPA treatment, the index of spleens and thymus was significantly increased, and the proliferation of spleen cells, the natural killer (NK) cell activity and phagocytosis activity of macrophages were prompted. Besides, EPA could reverse the decrease of CD4+ and CD8+ T lymphocytes induced by ovarian cancer. It was found that EPA could inhibit the phosphorylation status of PI3K (phosphatidylinositol 3-hydroxy kinase)/Akt (serine-threonine kinase), ERK1/2 (extracellular...
全文获取路径: Elsevier  (合作)
影响因子:2.632 (2012)

  • activity 活度
  • EPA Entry Point Address
  • ovarian 卵巢的
  • improving 改进
  • model 模型
  • tumor 肿胀
  • mechanism 机构