Pregnancy outcomes in women with epilepsy: A systematic review and meta-analysis of published pregnancy registries and cohorts
作者: Kimford MeadorMatthew W. ReynoldsSheila CreanKyle FahrbachCorey Probst
作者单位: 1Department of Neurology, University of Florida, Gainesville, FL, USA
2UnitedBioSource Corporation, Medford, MA, USA
刊名: Epilepsy Research, 2008, Vol.81 (1), pp.1-13
来源数据库: Elsevier Journal
DOI: 10.1016/j.eplepsyres.2008.04.022
关键词: AnticonvulsantsAnti-epileptic drugsCongenital malformationsPregnancyEpilepsyFetus
原始语种摘要: Summary(#br)Purpose(#br)To conduct a systematic review and meta-analysis to quantify the incidence of congenital malformations (CMs) and other pregnancy outcomes as a function of in utero anti-epileptic drug (AED) exposure.(#br)Methods(#br)We performed a systematic literature review to identify all published registries and cohort studies of births from pregnant women with epilepsy (WWE) that reported incidence of CMs. Overall incidences were calculated using a random effects model.(#br)Results(#br)The review included 59 studies that met inclusion/exclusion criteria, involving 65,533 pregnancies in WWE and 1,817,024 in healthy women. The calculated incidence of births with CM in WWE [7.08%; 95% CIs 5.62, 8.54] was higher than healthy women [2.28%; CIs 1.46, 3.10]. Incidence was highest for...
全文获取路径: Elsevier  (合作)
影响因子:2.241 (2012)

  • epilepsy 癫痫
  • epileptic 癫痫
  • systematic 有系统的
  • review 复审
  • published 公布的
  • phenytoin 苯妥英
  • incidence 入射
  • congenital 先天的
  • monotherapy 硫化物
  • literature 文献