Impact of the Expression of Epidermal Growth Factor, Transforming Growth Factor Alpha, and Epidermal Growth Factor Receptor on the Prognosis of Superficial Bladder Cancer
作者: Levent N TürkeriMustafa L Ertonİbrahim ÇevikAtif AkdaŞ
作者单位: 1Department of Urology, “Ergun Özalp” Research Laboratory, School of Medicine, Marmara University, İstanbul, Turkey
刊名: Urology, 1998, Vol.51 (4), pp.645-649
来源数据库: Elsevier Journal
DOI: 10.1016/S0090-4295(97)00648-1
原始语种摘要: Abstract(#br)Objectives. To investigate the correlation of epidermal growth factor receptor (EGFR) expression and its ligands EGF and transforming growth factor-alpha (TGF-α) with disease outcome in a cohort of patients with superficial bladder cancer.(#br)Methods. Tumor samples of 21 patients with transitional cell carcinoma of the bladder were analyzed by immunohistochemistry for expression of EGFR, EGF, and TGF-α. Disease-related events were recorded during a routine clinical follow-up and analyzed for possible correlation with the expression status of the above-mentioned proteins.(#br)Results. All Stage pT1 transitional cell carcinomas expressed EGFR, and 10 of 21 (48%) tumors showed focal areas of strong EGF and/or TGF-α expression. Of these, 80% with EGF positivity (8 of 10) had...
全文获取路径: Elsevier  (合作)
影响因子:2.424 (2012)

  • expression 表示
  • EGF 表皮生长因子
  • expressed 榨出的
  • related 有关的
  • bladder 膀胱
  • observed 观察到的
  • transitional 过渡的
  • superficial 表面的
  • confirmed 已确认的
  • whereas 鉴于