Clinical and Prognostic Value of Chaperonin Containing T-complex 1 Subunit 3 in Hepatocellular Carcinoma: A Study Based on Microarray and RNA-sequencing with 4272 cases
作者: Jiayin HouHuayu WuRongquan HePeng LinYiwu DangGang Chen
作者单位: 1Department of Pathology, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region 530021, China
2Department of Cell Biology and Genetics, School of Preclinical Medicine, Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region 530021, China
3Department of Medical Oncology, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region 530021, China
4Department of Ultrasonography, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region 530021, China
刊名: Pathology - Research and Practice, 2018
来源数据库: Elsevier Journal
DOI: 10.1016/j.prp.2018.11.006
关键词: Hepatocellular carcinomaCCT3DEGsPrognosisRNA sequencingClinicopathological parameters
原始语种摘要: Abstract(#br)Liver cancer is one of the few tumors with a steadily increasing morbidity and mortality; hepatocellular carcinoma (HCC) is the most common type of primary liver cancer. We combined the expression profiles of Chaperonin Containing T-complex 1 Subunit 3 (CCT3) in HCC tissues based on microarray and RNA-sequencing data. The CCT3 expression levels were extracted and examined based on 421 samples from The Cancer Genome Atlas (TCGA) (HCC, n = 371; non-HCC, n = 50) and 3851 samples from 31 microarray or RNA-sequencing datasets (HCC, n = 1975; non-tumor = 1876). We used a variety of meta-analytic methods, including SMD forest maps, sensitivity analysis, subgroup analysis and sROC curves, to confirm the final results. Meanwhile, database-derived immunohistochemistry data was used for...
全文获取路径: Elsevier  (合作)
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影响因子:1.213 (2012)

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关键词翻译
关键词翻译
  • sequencing 排序
  • RNA ROYAL NEPAL AIRLINES CORP.
  • expression 表示
  • complex 超群
  • CCT Control Central Tracking
  • expressed 榨出的
  • might 能力
  • analysis 分析
  • alteration 蚀变
  • common 普通