A small molecule activator of SIRT3 promotes deacetylation and activation of manganese superoxide dismutase
作者: Jiaqi LuHua ZhangXian ChenYong ZouJiasong LiLi WangMinhao WuJianye ZangYang YuWei ZhuangQing XiaJiangyun Wang
作者单位: 1Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of Sciences, Chaoyang District, Beijing 100101, China
2State Key Laboratory of Natural and Biomimetic Drugs, Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China
3Department of Physics, Jilin University, Changchun 130012, China
4Guangzhou Institute of Chemistry, Chinese Academy of Sciences, Tianhe District, Guangzhou 510650, China
5Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, China
6School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230026, China
7Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China
8State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, Inner Mongolia University, Huhhot, 010021,China
刊名: Free Radical Biology and Medicine, 2017, Vol.112 , pp.287-297
来源数据库: Elsevier Journal
DOI: 10.1016/j.freeradbiomed.2017.07.012
关键词: MnSODSIRT3AcetylationSuperoxideElectrostatic potential
原始语种摘要: Abstract(#br)The modulation of protein acetylation network is a promising strategy for life span extension and disease treatment (Sabari et al., 2016; Giblin et al., 2014) [1,2]. A variety of small molecules have been developed to target deacetylases, but extremely few of these molecules are capable of activating the mitochondrial NAD-dependent deacetylase sirtuin-3 (SIRT3) (Gertz and Steegborn, 2016; Scholz et al., 2015) [3,4]. Manganese superoxide dismutase (MnSOD) is the major superoxide scavenger in mitochondria, whose activity is regulated by SIRT3-mediated deacetylation, particularly at the Lys68 site (Chen et al., 2011) [5]. To investigate the influence of Lys68 acetylation on MnSOD activity, we produced a mutant MnSOD protein-bearing N-acetyllysine (AcK) at its Lys68 position...
全文获取路径: Elsevier  (合作)
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影响因子:5.271 (2012)

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关键词翻译
关键词翻译
  • superoxide 过氧化物
  • deacetylation 脱乙酰基
  • activator 活化剂
  • activation 活化
  • activity 活度
  • methoxyphenyl 甲氧苯基
  • repertoire 指令表
  • mitochondria 线粒体
  • scavenger 食腐动物
  • molecule 分子